AIDS – Things Are Good

HIV Vaccine Showing Promising Results

There are lots of teams trying to create a vaccine for HIV and they are all making valuable progress. HIV is the virus that turns into AIDS which is a life altering diagnosis. Treatments for people with HIV/AIDS have improved greatly over the decades but a vaccine would be the greatest step forward. This new vaccine works at the cellular level to help the body fight off HIV by boosting B cells. Modern science truly is impressive!

The new vaccine works by intervening in a process called B cell maturation. B cells make antibodies. Like many immune cells, B cells have an early “naive” stage before they are ready to make antibodies. B cells start to mature once they get the signal that a pathogen, such as a virus, is trying to attack. B cells see pieces of that pathogen’s molecular structure and start producing antibodies that can bind to that structure and halt infection.

It can take a little while for B cells to find the right “bullseye” on a pathogen. But B cells keep trying. As they mature, B cells tweak their antibody production, refining antibody structures to bind to a pathogen in just the right, vulnerable spots.

Scientists describe B cell development as a training process or bootcamp. In most cases, the body is left with a well-honed B cell army.

HIV is hard to beat because it doesn’t give B cells a chance to develop effective antibodies. The first problem is that HIV disguises itself from the immune system. The virus is wrapped in an ever-shifting cloak of sugar molecules, called glycans. This lets HIV sneak undetected past human cells, which are also covered in glycans.

Gamers Solve AIDS Enzyme Puzzle

If you thought playing games was just for fun, well Foldit is a game that has people solve problems for science. That itself is pretty neat, but what pushes this one over the edge is that Foldit has brought some great results and fast!

Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids — the building blocks of proteins — using a set of online tools.
To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks.
Cracking the enzyme “provides new insights for the design of antiretroviral drugs,” says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV).
It is believed to be the first time that gamers have resolved a long-standing scientific problem.
“We wanted to see if human intuition could succeed where automated methods had failed,” Firas Khatib of the university’s biochemistry lab said in a press release.

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Thanks Kathryn!

Vaginal Gel Cuts HIV Infections by Half

The International Aids Conference is currently underway in Vienna right now and some exciting news has been announced there. A new vaginal gel containing an AIDs drug is excellent at curtailing HIV infections.

The gel was found to be both safe and acceptable when used once in the 12 hours before sex and once in the 12 hours after sex by women aged 18 to 40 years.

Salim Abdool Karim, one of the two leading co-researchers, told reporters in Vienna that the 889 women involved in the trial, conducted in the coastal city of Durban and a remote rural village, had largely used the gel as directed.

They were also given condoms and advice about sexually transmitted diseases, and tested for HIV once a month.

After 30 months, 98 women became infected with HIV – 38 in the group that got tenofovir in the gel and 60 in the group that got placebos.

Buy Things, Fight AIDS

A new organization called RED created a bit of a buzz this World AIDS Day. Along with the backing of the usual Irish rock singers and African soccer players, they’ve partnered with a number of major corporations to raise both awareness and funds. Apple, Nike, Starbucks and Facebook are some of the names involved. This means you can buy an iPod, and some of the cash you spend will go to The Global Fund. Just in time for the holidays!

(RED)â„¢ is a simple idea that transforms our collective power as shoppers into a financial force that helps those affected by HIV in Africa. To date, $140 million has been generated and 4 million people have been helped through Global Fund programs that (RED) supports. When you choose to buy products from (RED) partner companies up to 50% of the profit goes towards eliminating AIDS in Africa.

Malawi Handing Out Free Drugs

The African country of Malawi is expanding a successful program that gave out free drugs to fight AIDs. The country is founding a new company to make the drugs for their people and to export drugs to their neighbours.

“Some 250,000 Malawians are receiving ARVs. We are doing well because many of these could have died by now,” Mutharika said at an AIDS candlelight memorial on the outskirts of the commercial capital Blantyre.

Describing the drugs roll-out as a “success story”, Mutharika said Malawi would establish a local company to “produce ARVs locally and export extra drugs to neighbouring countries”.